5 mL of distilled water is added to test tube A. The objective of this experiment is to enable us to conduct the synthesis of aspirin, reinforce the skills of recrystallisation and reinforce the technique of melting point determination. In this experiment aspirin, also known as acetylsalicylic acid, was synthesized … Analgesic (painkiller)! RELATED WORK: Synthesis of Aspirin Lab Report . Introduction: Charles Frederic Gerhardt, a French chemist was the first to prepare aspirin in 1853. Antipyretic (fever reducer)! Aspirin Synthesis and Analysis. Chem. and they were labeled #1 – 4. The methods used included recrystallization and scratching to produce a precipitate, which was then filtered to remove any excess moisture. ; Heat the flask gently on the steam bath for at least 10 minutes. The purification technique of recrystallization is very effective, as long as the temperature is lowered slowly enough that very pure crystals are formed. Question: Synthesis Of Aspirin Lab 1) In Part 1 Of This Experiment , You Will Synthesize Aspirin A) Salicylic Acid Reacts With Acetic Acid To Produce Aspirin And Water. Aspirin is an ester that has high molecular weight and it not soluble in water hence the solid can be separated by crystallization process. In this experiment, you will prepare aspirin from salicylic acid and acetic anhydride using sulfuric acid as a catalyst. Preparation of Aspirin Lab Report. Feb 2014; M El-Magbri; El-Magbri, M. (2014, February 26). ...Experimental Synthesis of Aspirin and Melting Point Purity Analysis Donald Yeargin CH 222, Section 24221 Department of Chemistry Portland Community College Portland, OR Abstract The various methods available to synthesize aspirin lead to the need to examine and evaluate production efficiency and purity. This polymer was not transferred to the solution with water, reducing yield. Thus, unknown compound B was determined to be impure acetylsalicylic acid. In this experiment, you will prepare aspirin from salicylic acid and acetic anhydride using sulfuric acid as a catalyst. During the lab aspirin was synthesized, purified, and analyzed. • Take a small amount of the aspirin tablet and dissolve as much as you can in 3 drops of ethyl acetate. Course Organic Chemistry (CHEM 2370 ) Academic year App. Synthesis of Aspirin Lab Report. Synthesis of Aspirin … Prolonged contact with acid catalyst in the presence of water can lead to regeneration of salicylic acid starting material and reduce acetylsalicylic acid yield. Aspirin is a drug that is usually used to relieve minor aches and pain and other medical uses such as anti-inflammatory medication. The Synthesis of Aspirin 1. The purpose of this experiment is to synthesize the common pain killer aspirin via an esterification reaction between Salicylic Acid and Acetic Anhydride in the presence of concentrated sulfuric acid acting as a catalyst. PROCEDURE. This procedure was repeated using pyridine (5 drops), boron trifluoride etherate (5 drops), then concentrated sulfuric acid (5 drops) as the catalyst. Patented by Bayer in 1893! It is 0000001234 00000 n Rasan Cherala Synthesis of Aspirin lab Purpose: The purpose of this experiment is to create aspirin by reacting salicylic acid with acetic anhydride. 1. The purity of the sample will be qualitatively determined with melting point analysis. Synthesis and analysis of aspirin formal lab report >>> next Stem cells controversy essay Writing prompts for ks1 in the interim, ill be available at 201 or via email at email regents prep us history government exam overview: dbq essay. An ester is a compound that is formed when an acid reacts with an alcohol, -OH group. A small mass of one of four different unknown solid compounds was added to each tube. Aspirin Synthesis and Analysis. Synthesis and Spectral Analysis of Aspirin By: Nikki Goeddeke Lab Partner: Casey Goettel March 19, 2015 Organic Chemistry II Section 21 Introduction Purpose The purpose of this experiment is to synthesize and analyze aspirin by the esterification of salicylic acid to aspirin using acetic anhydride. Aspirin Synthesis and Analysis Lab Report Malia Mandl Partner: Cosette Motta TA: Zhipeng Zheng Purpose: The purpose of this lab is to synthesize aspirin and measure its impurities. Pyridine also activates the electrophile by reacting with acetic anhydride to form the N-acyliminium ion, as seen in Figure 3. Lower absorbance values would indicate that a greater concentration of phenol was present and the absorbance value could be used to directly determine the concentration, 1 Cappelli, G. J. Chem. 1) A student prepared aspirin using 2.019 g of salicylic acid and 5.2 mL of acetic anhydride (d = 1.08 g/mL). 0000004555 00000 n 0000003774 00000 n The results displayed a percent yield of 34.3%, from a theoretical yield of about 1.97g of aspirin and an actual yield of approximately 0.68g of aspirin. Exothermic side reactions would increase the reaction temperature more quickly even if the salicylic acid acetylation rate had not changed. Members of the class may have also utilized different techniques to measure the time taken for a 4 ˚C temperature change to occur. Synthesis and analysis of aspirin formal lab report >>> next page Apa essay heading format A piece is generally considered an essay if it is between 10,00018,000 words cornell law review is a signatory to the joint statement on article length. The sodium acetate experiment is the trial that all members of the class performed first, so their techniques were not yet refined. If you need guidance, follow the steps in the Report Sheets. This product will be impure because of unreacted salicylic acid and visible spectroscopy can help determine the percentage of the impurity of the product. Upon completion of the lab, analysis, and calculations, it is evident that the synthesis of aspirin is possible using these … Conclusion Synthesis Of Aspirin Lab Jennie K. Daniels Organic Chemistry 2121 11 February 2014 Synthesis of Aspirin Salicylic acid derivatives, or salicin, are found in the bark of the willow tree In the 5th century B.C., Hippocrates ground the bark into a powder, and later, the Natives Americans chewed on the bark to alleviate fever and pain1. This would reduce yield and shift equilibrium toward the reverse reaction. The efficacy of the recrystallization could have been analyzed by determining the melting point range of the acetylsalicylic acid. 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